The Loppnow group is primarily interested in the interaction of light with biomolecules, the chemical and physical mechanisms of such interactions, and their exploitation for analytical purposes. More specifically, we are examining nucleic acid damage, protection, and repair; photosynthesis and respiration; vision; and solar energy cells. In addition, we are developing novel analytical tools and methods for biology. Tools of choice include spectroscopy, photochemistry, and microarray/microfluidic techniques.
Current projects within the Loppnow group include:
1. The role of structure in nucleobase damage
2. Nucleic acid damage, repair and protection microarrays
3. Novel tools and methods for biology.
The research program is very interdisciplinary, drawing on all four of the traditional areas of chemistry, as well as from the fields of physics and biology.
Yarasi, S., Brost, P., and Loppnow, G. R. 2007. Initial Excited-state Structural Dynamics of Thymine are Coincident with the Photochemical Reaction Coordinate. J. Phys. Chem. A 111, 5130-5135.
Billinghurst, B. E., Yeung, R., and Loppnow, G. R. 2006. Excited-state Structural Dynamics of 5-Fluorouracil. J. Phys. Chem. A 110, 6185-91.
Yarasi, S., McConachie, C., and Loppnow, G. R. 2005. Molecular beacon probes of photodamage in thymine and uracil oligonucleotides. Photochem. Photobiol. 81, 467-73.
Beyere, L., Arboleda, P., Monga, V., and Loppnow, G. R. 2004. The Dependence of Thymine and Thymidine Raman Spectra on Solvent. Can. J. Chem. 82, 1092-1101.
Shoute, L. C. T., and Loppnow, G. R. 2003. Excited-state Metal-to-Ligand Charge Transfer Dynamics of a Ruthenium(II) Dye in Solution and Adsorbed on TiO2 Nanoparticles from Resonance Raman Spectroscopy. J. Am. Chem. Soc. 125, 15636-15646.
Beyere, L., Yarasi, S., and Loppnow, G. R. 2003. Solvent Effects on Sunscreen Active Ingredients using Raman Spectroscopy. J. Raman Spectrosc. 34, 743-750.
Fraga, E., and Loppnow, G. R. 2002. The Role of Specific Amino Acid Residues in the Vibrational Properties of Plastocyanin. J. Phys. Chem. B 106, 10474-10481.